Pradipta Ghosh

Pradipta Ghosh

Pradipta Ghosh, MD

Dr. Ghosh obtained her medical degree from Christian Medical College, Vellore in India. She graduated in 2000 as the 'Best Outgoing Student in Medicine, Surgery' and 'Overall Best Outgoing Student' adjudged by the Indian Medical Association on a nationwide ranking. She started her career in science as a research associate training under Dr Stuart Kornfeld at the Washington University, St. Louis, Missouri in 2001 before beginning her internship and residency in Internal Medicine here at UCSD in 2003. Dr. Ghosh is currently in her final year with the UCSD Gastroenterology Fellowship Program and is working in the George Palade laboratories under the mentorship of Dr. Marilyn G. Farquhar.

Research Publications

  1. Ghosh, P., Garcia-Marcos, M, Bornheimer, J. and Farquhar MG. Gai3 behaves as a Molecular switch that dictates formation of the leading edge during migration. Submitted 2007.
  2. Ghosh, P.*, Doray, B.*, Griffith, J., Geuze, H.J. and Kornfeld, S. :Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. Science. 2002 Sep 6;297(5587):1700-3. (*Equal contribution 1st and 2nd authors)
  3. Ghosh, P., Dahms, N.M. and Kornfeld, S: Mannose 6-phosphate receptors: new twists in the tale. Nature Rev Mol Cell Biol. 2003 Mar;4(3):202-12.
  4. Ghosh, P., Griffith, J., Geuze, H.J. and Kornfeld, S. : Mammalian GGAs act together to sort mannose 6-phosphate receptors. J Cell Biol. 2003 Nov 24;163(4):755-66.
  5. Ghosh, P. and Kornfeld, S.: AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation. J Cell Biol. 2003 Mar 3;160(5):699-708. Epub 2003 Feb 25.
  6. Ghosh, P. and Kornfeld, S.: GGA proteins: Key Players in Protein Sorting at the Trans-Golgi network. Eur. J Cell Biol, 2004, 83: (6)- 257-262.
  7. Ghosh, P. and Kornfeld , S. : The cytoplasmic tail of the cation-independent mannose 6-phosphate receptor contains four binding sites for AP-1. Arch Biochem Biophys. 2004 15;426(2):225-30.
  8. Ghosh, P. and Kornfeld, S.: Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network. J Biol Chem. 2003 Apr 18;278(16):14543-9. Epub 2003 Feb 10.
  9. Doray, B., Bruns, K., Ghosh, P. and Kornfeld, S: Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8072-7.
  10. Do, H., Lee, W.S., Ghosh, P., Hollowell, T., Canfield, W. and Kornfeld, S: Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin. J Biol Chem. 2002 Aug 16; 277(33):29737-44.
  11. Doray, B., Bruns, K., Ghosh, P. and Kornfeld, S: Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. J Biol Chem. 2002 May 24; 277(21):18477-82.

Other Publications

  1. Ghosh P, Strong C, Naugler W, Haghighi P, Carethers JM. Peritoneal mice implicated in intestinal obstruction: report of a case and review of the literature. J Clin Gastroenterol. 2006 May-Jun;40(5):427-30.
  2. Ghosh, P, Santosa, A.C., Lin GY, Downs TM: De novo calcification of liver and nodal metastases in prostate carcinoma. Prostate Cancer Prostatic Dis. 2006 May 9. (Nature Publishing Group).
  3. Ghosh, P, Miyai, K and Chojkier, M. Gastric adenocarcinoma inducing portal hypertension: a rare presentation. World J Gastroenterol. 2007 Feb 14;13(6):960-3.
  4. Ghosh, P and Jung, B: Giant Paraesophageal Hernia Causing Compression Pulmonary Atelectasis: Starved for Air when Satiated with Food. J Gastroenterol and Hepat. 2007 Apr;22(4):595.
  5. Ghosh, P., Olson, RK. and Harmon, G: Sugar Rush in the Colon: Why Incidental Findings on PET scan Justify Colonoscopy?, Amer J. Gastro, in press, 2007
  6. Ghosh, P and Kum, J. Mesenteric panniculitis and sclerosing mesenteritis: a continuum of inflammation fibrosis. Clin Gastroenterol Hepatol. 2007 May;5(5):A32.
  7. Lee JK., Kum J., Ghosh, P. Gastrointestinal: Glycogenic acanthosis. J Gastroenterol Hepatol. 2007 Sep;22(9):1550.
  8. Lee JK and Ghosh, P. Non-metastatic cancer of the colon associated with pyogenic liver abscess. Amer. J. Gastro, in press 2007.
  9. Lee, JK., Ghosh, P., McWhorter, V., Payne, M., Olson, RK., Ramamoorthy, S., Krinsky, ML., Carethers, JM. Evidence that rectal sarcomatoid carcinoma arises from tubulo-villous adenoma: Tumorigenesis caught in the act. Submitted, 2007.

Books

  1. Medicine Manual 1st Edn- 2000; 2nd Edn 2002- A 300+ page comprehensive pocket book for the interns and residents in Internal Medicine; Copyright Christian Medical College and Hospital, Vellore.