Administrative Assistant

  • Justin Maisonet

Scientists

  • Angela Glading, Ph.D.
  • Brian Petrich, Ph.D.
  • Chloe Feral, Ph.D.
  • ChungHo Kim, Ph.D.
  • Eugene Tkachenko, Ph.D.
  • Hosup Lee, Ph.D.
  • James Lim, Ph.D.
  • Joe M. Cantor, Ph.D.
  • Larry Goldfinger, Ph.D.
  • Per Fogelstrand, Ph.D.
  • Rebecca Stockton, Ph.D.
  • Feng Ye, Ph.D.

Research Associates

Students

  • Asoka Banno, Ph.D. candidate
  • Jake Haling, Ph.D. candidate
  • Matthew Fradkin, M.S. candidate
Wilma McLaughlin, Lab Manager
wilma@ucsd.edu
  1. Takada Y, Ylanne J, Mandelman D, Puzon W, Ginsberg MH. A point mutation of integrin b1 subunit blocks binding of a5b1 to fibronectin and invasin but not recruitment to adhesion plaques. J Cell Biol. 1992;119:913-921.
  2. Takada Y, Puzon W. Identificatin of a regulatory region of integrin b1 subunit using activating and inhibiting antibodies. J Biol Chem. 1993;268:17597-17601.
  3. Kamata T, Puzon W, Takada Y. Identification of putative ligand binding sites within I domain of integrin a2b1 (VLA-2, CD49b/CD29). J Biol Chem. 1994;269:9659-9663.
  4. Irie A, Kamata T, Puzon-McLaughlin W, Takada Y. Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits. EMBO J. 1995;14:5550-5556.
  5. Kamata T, Puzon W, Takada Y. Identification of Putative Ligand-Binding Sites of the Integrin a4b1 (VLA-4, CD49d/CD29). Biochem J. 1995;305:945-951.
  6. Faull RJ, Wang J, Leavesley DI, Puzon W, Russ GR, Vestweber D, Takada Y. A novel activating anti-beta1 integrin monoclonal antibody binds to the cysteine-rich repeats in the beta1 chain. J Biol Chem. 1996;271:25099-25106.
  7. Luque A, Gomez M, Puzon W, Takada Y, Sanchez-Madrid F, Cabanas C. Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355- 425) of the common beta 1 chain. J Biol Chem. 1996;271:11067-11075.
  8. Matsuura N, Puzon-McLaughlin W, Irie A, Morikawa Y, Kakudo K, Takada Y. Induction of experimental bone metastasis in mice by transfection of integrin alpha 4 beta 1 into tumor cells. Am J Pathol. 1996;148:55-61.
  9. Puzon-McLaughlin W, Takada Y. Critical residues for ligand binding in an I domain-like structure of the integrin b 1 subunit. J Biol Chem. 1996;271.
  10. Puzon-McLaughlin W, Yednock TA, Takada Y. Regulation of conformation and ligand binding function of integrin alpha5beta1 by the beta1 cytoplasmic domain. J Biol Chem. 1996;271:16580-16585.
  11. Takada Y, Kamata T, Irie A, Puzon-McLaughlin W, Zhang XP. Structural basis of integrin-mediated signal transduction. Matrix Biol. 1997;16:143-151.
  12. Takagi J, Kamata T, Meredith J, Puzon-McLaughlin W, Takada Y. Changing ligand specificities of alphavbeta1 and alphavbeta3 integrins by swapping a short diverse sequence of the beta subunit. J Biol Chem. 1997;272:19794-19800.
  13. Mould AP, Garratt AN, Puzon-McLaughlin W, Takada Y, Humphries MJ. Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1. Biochem J. 1998;331 ( Pt 3):821-828.
  14. Zhang XP, Kamata T, Yokoyama K, Puzon-McLaughlin W, Takada Y. Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. J Biol Chem. 1998;273:7345-7350.
  15. Prokopishyn NL, Puzon-McLaughlin W, Takada Y, Laferte S. Integrin alpha3beta1 expressed by human colon cancer cells is a major carrier of oncodevelopmental carbohydrate epitopes. J Cell Biochem. 1999;72:189-209.
  16. Zhang XP, Puzon-McLaughlin W, Irie A, Kovach N, Prokopishyn NL, Laferte S, Takeuchi K, Tsuji T, Takada Y. Alpha 3 beta 1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between alpha 3 N-terminal repeats 2 and 3. Biochemistry. 1999;38:14424-14431.
  17. Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem. 2000;275:34922-34930.
  18. Puzon-McLaughlin W, Kamata T, Takada Y. Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3). J Biol Chem. 2000;275:7795-7802.
  19. Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem. 2002;277:17804-17810.
  20. Kamata T, Tieu KK, Tarui T, Puzon-McLaughlin W, Hogg N, Takada Y. The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1). J Immunol. 2002;168:2296-2301.
  21. Levesque JP, Takada Y, Puzon-McLaughlin W, Simmons PJ. A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29). Hybrid Hybridomics. 2002;21:253-260.
  22. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002;115:2199-2206.
  23. Kariya Y, Tsubota Y, Hirosaki T, Mizushima H, Puzon-McLaughlin W, Takada Y, Miyazaki K. Differential regulation of cellular adhesion and migration by recombinant laminin-5 forms with partial deletion or mutation within the G3 domain of alpha3 chain. J Cell Biochem. 2003;88:506-520.
  24. Kamata T, Ambo H, Puzon-McLaughlin W, Tieu KK, Handa M, Ikeda Y, Takada Y. Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit. Biochem J. 2004;378:1079-1082.